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You can also search for this author in PubMed Google Scholar. Correspondence to Byung-Soo Kim. Reprints and Permissions. Yang, H. Comparison between heparin-conjugated fibrin and collagen sponge as bone morphogenetic protein-2 carriers for bone regeneration. Exp Mol Med 44, — Download citation.
Accepted : 06 February Published : 10 February Issue Date : May Also they are not formed by an intracellular action, but arise directly by a transformation of the fibrin elements of the plasma clot.
Experiments have been made which indicate that the transformation of the fibrin net will not occur unless it has come under the influence of living tissues or of living isolated cells. However, mechanical means, such as exerting tension on the clot with needles, may hasten the formation of the fibers. Also, in some cultures, movements of living isolated cells appear to aid in the formation of the fibers.
The living tissues alone, however, are able to cause the fibers to form without the aid of any apparent mechanical factor. This is shown by cultures of various tissues in which no cell movement occurs and in which the plasma clot is undisturbed and yet a prolific formation of fibers may take place.
Experiments have been made in order to determine the true nature of the transformed plasma clot and to see if the new fibrous tissue were still fibrin in character. The results that have so far been obtained from these tests have not been entirely conclusive and leave the question unsettled.
The transformation of the fibrin net results in a shrinkage of the clot. It also becomes very tough and resistant to injury and, therefore, entirely different from the fragile and easily destroyed fibrin net when in its original condition.
It is believed that such a reaction must play an important part in wound healing. A study of the relation between connective tissue fibers formed in wound healing and in embryonic development to the fibers formed in the plasma clot is being made, and the results will appear in a later paper.
Sign In or Create an Account. Advanced Search. User Tools. Cells attached to the tissue culture polystyrene and showed a healthy morphology c. Cells continued to proliferate d and formed confluent monolayer at day 21 e [ 53 ]. Figure 8. Alizarin staining for the synthesis of bone mineral at 7, 14, and 21 days. The calcium minerals are stained in red. The mineral concentration was measured by osteogenesis assay and the results are shown in d.
The mineral concentration at day 21 is fold higher than day 7, which demonstrated cells released from microbeads synthesized bone mineral successfully [ 53 ]. References U. Jockenhoevel, G. Zund, S. Hoerstrup et al. Grad, L. Kupcsik, K.
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