Read our disclaimer for details. Recruitment status was: Recruiting First Posted : April 28, Last Update Posted : April 28, Study Description. Helicobacter pylori is a bacterium estimated to colonize in the gastrointestinal tract of the half population in the world. Colonization of this bacteria is suspected to be one of the main risk factor for the occurrence of various abnormalities of the upper gastrointestinal tract, such as peptic ulcer and gastrointestinal cancer.
The Experts recommend giving triple therapy regimens as first-line eradication therapy for Helicobacter pylori infection. The recommended duration of triple therapy is days. However, recent studies suggest triple therapy with longer duration will provide a higher percentage of eradication. This study wanted to show whether 14 days of triple therapy was better than 10 days in Helicobacter pylori eradication.
Detailed Description:. FDA Resources. Arms and Interventions. Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Inclusion Criteria: 18 years or older patients who are proven to be infected by Helicobacter pylori based on positive in Urea Breath Test or positive in histopathologic examination of biopsy in antrum and corpus of gaster through esophagoduodenoscopy.
Exclusion Criteria: Patients refuse to follow the research Patient has had previous eradication therapy of Helicobacter pylori infection. Patients are known to have impaired liver function, evidenced by ALT values within normal limits, and no previous liver disease. Patients were found to have arrhythmias or obtained QT wave elongation on electrocardiographic.
Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
The optimal duration for Helicobacter pylori H. Several systematic reviews have attempted to address this issue but have given conflicting results and limited their analysis to proton pump inhibitor PPI , two antibiotics PPI triple therapy.
We performed a systematic review and meta-analysis to investigate the optimal duration of multiple H. The primary objective was to assess the relative effectiveness of different durations 7, 10 or 14 days of a variety of regimens for eradicating H. The primary outcome was H. The secondary outcome was adverse events.
We also searched the proceedings of six conferences from to , dissertations and theses, and grey literature. There were no language restrictions applied to any search.
Only parallel group RCTs assessing the efficacy of one to two weeks duration of first line H. Within each regimen, the same combinations of drugs at the same dose were compared over different durations. Studies with at least two arms comparing 7, 10, or 14 days were eligible.
Enrolled participants needed to be diagnosed with at least one positive test for H. Eligible trials needed to confirm eradication of H. Trials using only serology or a polymerase chain reaction PCR to determine H. At this point, the clinician should attempt to culture the organism and obtain antibiotic sensitivities.
This is not commonly done and requires a laboratory that specializes in H pylori antibiotic sensitivity testing. It is clear that eradication of H pylori is important in ulcer disease; however, the confusion comes with which regimen to choose.
From our review of the literature on eradication, it has become clear that 7- to day regimens containing a proton pump inhibitor in combination with metronidazole and clarithromycin are highly efficacious and well tolerated. Unfortunately, as more and more patients receive eradication therapy, antibiotic resistance will become a growing problem, especially as the prevalence of clarithromycin resistance increases.
As a result, antibiotic sensitivity testing will play a greater role in the future of eradication therapy. Still, there are presently very effective regimens against H pylori ; however, the search for improved treatments requiring fewer pills and shorter courses continues. Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy Continue. View Large Download. Most Effective Regimens for the Eradication of Helicobacter pylori.
Soll AH Medical treatment of peptic ulcer disease: practice guidelines. N Engl J Med. J Clin Pathol. Inhibitory antimicrobial concentrations against Campylobacter pyloridis in gastric mucosa. J Antimicrob Chemother. Amoxycillin plus tinidazole for Campylobacter pylori gastritis in children: assessment by serum IgG antibody, pepsinogen I, and gastrin levels. Campylobacter pyloridis— associated chronic active antral gastritis: a prospective study of its prevalence and the effects of antibacterial and antiulcer treatment.
Marshall BJ Treatment strategies for Helicobacter pylori infection. Gastroenterol Clin North Am. Effect of omeprazole on the distribution of metronidazole, amoxicillin, and clarithromycin in human gastric juice. Prevention of nitroimidazole resistance in Campylobacter pylori by coadministration of colloidal bismuth subcitrate: clinical and in vitro studies.
Short report: omeprazole plus antibiotic combinations for the eradication of metronidazole-resistant Helicobacter pylori. Aliment Pharmacol Ther. Metronidazole resistance in Helicobacter pylori [letter]. European Study Group on Antibiotic Susceptibility of Helicobacter pylori, Results of a multicenter European survey in of metronidazole resistance in Helicobacter pylori.
A prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Am J Gastroenterol. Omeprazole, bismuth, and clarithromycin: a new approach to the treatment of H pylori —related gastritis [abstract].
Clarithromycin as monotherapy for eradication of Helicobacter pylori : a randomized, double-blind trial. Susceptibility of Campylobacter pylori to macrolides and fluoroquinolones. Glupczynski YBurette A Failure of azythromycin to eradicate Campylobacter pylori from the stomach because of acquired resistance during treatment [letter].
Triple therapy with azithromycin, omeprazole, and amoxicillin is highly effective in the eradication of Helicobacter pylori : a controlled trial versus omeprazole plus amoxicillin. The effect of GRX, a bismuth compound with H 2 -antagonist activity, on hour intragastric acidity.
Ranitidine bismuth citrate: a novel antiulcer agent with different physicochemical characteristics and improved biological activity to a bismuth citrate-ranitidine admixture.
Effect of administration of ranitidine bismuth citrate with food on the suppression and eradication of Helicobacter pylori in infected volunteers. GRX ranitidine bismuth citrate , a new drug for the treatment of duodenal ulcer. Ranitidine bismuth citrate plus clarithromycin is effective for healing duodenal ulcer, eradicating H pylori , and reducing ulcer recurrence.
Dixon JS Helicobacter pylori eradication: unravelling the facts. Scand J Gastroenterol. Therapy of Helicobacter pylori infection: clinical trials with double and triple pharmacological association. Ital J Gastroenterol. Decreased relapse rate after antibacterial treatment of Helicobacter pylori —associated duodenal ulcers: Munich Duodenal Ulcer Trial.
Eur J Gastroenterol Hepatol. Axon A The role of omeprazole and antibiotic combinations in the eradication of Helicobacter pylori. Long-term follow up after eradication of Helicobacter pylori with a combination of omeprazole and amoxycillin. An increasing dose of omeprazole combined with amoxycillin increases the eradication of Helicobacter pylori [abstract]. High dose proton pump inhibitors plus amoxycillin for the treatment or retreatment of Helicobacter pylori infection. Abramowicz Med Clarithromycin and omeprazole for Helicobacter pylori.
Med Lett. Logan RPHBardhan KDCelestin LR Eradication of Helicobacter pylori and prevention of recurrence of duodenal ulcer: a randomized, double-blind, multicenter trial of omeprazole with or without clarithromycin.
Not Available, U. Study M [package insert]. North Chicago, Ill Abbott Laboratories. Chiba N Omeprazole and clarithromycin with and without metronidazole for the eradication of Helicobacter pylori. The dose and frequency of omeprazole are important in treating H pylori with dual therapy [abstract]. Efficacy of lansoprazole in eradication of Helicobacter pylori. J Clin Gastroenterol.
Markham AMcTavish D Clarithromycin and omeprazole: as Helicobacter pylori eradication therapy in patients with H pylori —associated gastric disorders. Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pylori. Antimicrob Agents Chemother.
Evaluation of the pharmacokinetic drug interactions between clarithromycin and omeprazole. GRX ranitidine bismuth citrate with antibiotics for the eradication of Helicobacter pylori [abstract].
Bismuth-based combination therapy for Helicobacter pylori —associated peptic ulcer disease metronidazole for eradication, ranitidine for pain. Triple therapy vs amoxicillin plus omeprazole for treatment of Helicobacter pylori infection: a multicenter, prospective, randomized, controlled study of efficacy and side effects.
Dual therapy v triple therapy for Helicobacter pylori -associated duodenal ulcers. Dig Dis Sci. Clarithromycin, tetracycline, and bismuth: a new nonmetronidazole therapy for Helicobacter pylori infection.
Azithromycin for the cure of Helicobacter pylori infection. Hunt RH Eradication of Helicobacter pylori infection. Am J Med. Factors influencing the eradication of Helicobacter pylori with triple therapy. Omeprazole coupled with two antibiotics for Helicobacter pylori eradication and prevention of ulcer recurrence.
Metronidazole, omeprazole, and clarithromycin: an effective combination therapy for Helicobacter pylori infection. Randomized comparison of 7, 10, 14 days of omeprazole, amoxicillin, and clarithromycin for treatment of H pylori [abstract]. Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer.
The efficacy of two classic antibiotics, tetracycline and metronidazole, alone or with ranitidine on duodenal ulcer healing and eradication of H pylori [abstract]. Holtmann GLayer PGoebell H Proton pump inhibitors or histamine 2 -receptor antagonists for Helicobacter pylori eradication: a meta-analysis.
Helicobacter pylori eradication therapy: a comparison between either omeprazole or ranitidine in combination with amoxycillin plus metronidazole [abstract]. Omeprazole enhances efficacy of triple therapy in eradicating Helicobacter pylori. Impact of metronidazole resistance on the eradication of Helicobacter pylori. Scand J Infect Dis. Role of metronidazole resistance in therapy of Helicobacter pylori infections.
Highly effective twice a day triple therapies for Helicobacter pylori infection and peptic ulcer disease: metronidazole resistance is of only minor importance [abstract]. Olson CEdmonds A Primary susceptibility of H pylori to clarithromycin compared to metronidazole in patients with duodenal ulcers associated with H pylori infection [abstract]. Pre- and post-treatment clarithromycin resistance of Helicobacter pylori strains: a key factor of treatment failure [abstract].
0コメント